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Simpson, S., Seifer, D
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In mice, numerous PAMPs produced by bacteria, viruses and fungi exacerbated NHO formation, and the majority of these PAMPs indirectly stimulated fibro-adipogenic progenitor (FAP) calcium mineralization in vitro via macrophages
Researchers raise doses in animals until roughly 50% die, giving a crude measure of acute lethality that does not translate directly to human safety but gives context for risk margins
adults consume less than the recommended amount, contributing to marginal deficiencies or inadequacies
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