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The advantage of cell-penetrating peptides over chemical enhancers is specificity
Moreover, LC administrated for 2 weeks suppresses atrogin-1 messenger RNA (mRNA) level in suspended rats hindlimb [35], and only 7 days of LC administration downregulates MuRF-1 and atrogin-1 mRNAs reducing muscle wasting in a rat model of cancer cachexia [32]
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v Similarly, increased oxidative stress in Alzheimers disease has been attributed to decreased levels of glutathione in the brain
The most common gastrointestinal side effects include: Nausea very common (may affect more than 1 in 10 people), most pronounced during the first 4-5 weeks Diarrhoea common (may affect up to 1 in 10 people) Vomiting common (may affect up to 1 in 10 people) Abdominal pain common (may affect up to 1 in 10 people) Constipation common (may affect up to 1 in 10 people) Dyspepsia and flatulence common (may affect up to 1 in 10 people) Whilst belching may occur, 'sulphur burps' are not specifically enumerated as a distinct adverse effect in the SmPC
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