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For general weight loss, GLP-1 and GIP/GLP-1 medications such as semaglutide and tirzepatide are more effective

Vollmer K, Holst JJ, Baller B, et al

The international scientific association for probiotics and prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

These include Rybelsus (oral semaglutide) for type 2 diabetes, oral Wegovy (semaglutide) for chronic weight management, and Foundayo (orforglipron), a newer oral GLP-1 medication approved for obesity treatment

These medicines improve health through reduction of blood glucose and body weight, by attenuation of inflammation and via direct activation of receptors in target tissues