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Starting at low doses (100250 mcg) and titrating up helps manage this

The study concluded that while PR-104 demonstrated biological proof-of-principle for targeting hypoxia and metabolic vulnerabilities in leukemia, its clinical use is constrained by toxicity, supporting the need for biomarker-guided selection and combination approaches rather than monotherapy (281)

Throwing Up on a GLP-1: Causes, Management and When to Seek Help Throwing up on a GLP-1 medication is a recognised side effect that affects a notable proportion of patients using these treatments for type 2 diabetes or weight management

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PMCID: PMC3016669