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Effects of GLP-1R activation in the heart The observation that GLP-1 decreases contractility in primary culture of adult rat cardiomyocytes, despite increasing cAMP levels, [38] has also been reported in isolated rat hearts [45]
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Control (sham-operated) animals underwent the same procedures, except that after the suture was passed around the LAD coronary artery, it was not drawn tight to occlude the vessel
Consistent with these functional deficits, SYK deficiency markedly decreased glucose uptake and intracellular levels of key glycolytic metabolites, including glucose-6-phosphate, pyruvate, and lactate (Fig
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