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Upregulation of angiotensin II can activate NADPH oxidase enzyme complex in vascular smooth muscle cells and cardiomyocytes, further increasing the generation of ROS and participating in the progression of HF (Doughan et al., 2008)

But interesting biology and plausible mechanisms are where drug development begins, not ends

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Continuous, daily usage without breaks is generally not recommended due to the lack of extensive human data and potential risks 1 2

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