Cystamine and disulfiram inhibit human transglutaminase 2 via an oxidative mechanism
Numerous direct or indirect inhibitors of these enzymes have been developed and mainly characterized in vitro
This, in turn, doubles the capacity of the available growth factors to promote signaling cascades necessary for mitogenesis (cell division), motogenesis (promotion of cellular motility), morphogenesis (structural development), neurogenesis (growth and development of nervous tissue), production of stem cells, and protection of a wide range of cells against injury
Anaemia of acute malaria infections in non-immune patients primarily results from destruction of uninfected erythrocytes
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