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The standard schedule is a starting point, not a strict rule The 2024 NICE guideline NG239 on B12 deficiency in over 16s makes an important point: the optimal route, dose and frequency of B12 replacement have never been firmly established, and have often followed custom and historical practice

Microcytic anemia (low MCV, typically below 80 fL) most commonly indicates iron deficiency, thalassemia, or anemia of chronic disease

[PMID: 23755725] PubMed record related to this compound for laboratory literature review

Vegans, vegetarians, people over the age 50, anyone with stomach/bowel issues like chronic gastritis, leaky gut, IBS or celiac, and anyone who regularly takes medications such as Metformin, PPIs (used for GERD), H2 Receptor Antagonists (used for peptic ulcers), or anything that interferes with stomach acid production are actually at risk for vitamin B12 deficiency, and should supplement B12 regularly

Safety evaluation: The safety of the cream is assessed through acute toxicity tests, long-term toxicity tests, etc., to ensure that it has no toxic or side effects