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The Science of Stability: Why Peptides Degrade Peptides are delicate structures

doi: 10.1016/j.cmet.2019.03.002 61 GrunddalKVJensenEPrskovCAndersenDBWindelvJAPoulsenSSet al

Evidence ranges from promising to preliminary depending on the peptide and indication

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While targeting extracellular collagen processing through LOX/LOXL inhibition has the potential to attenuate postischemic fibrosis, 232 clinical trials of LOXL2-blocking simtuzumab have proven ineffective due to enzymatic redundancy