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When comparing effectiveness, the Wegovy injection is generally considered significantly more effective for weight loss than oral alternatives

Safety Profile in Research Contexts Gastrointestinal events (nausea, vomiting, diarrhea, constipation) remain the most common adverse effects, typically mild to moderate, dose-dependent, and often mitigated by gradual dose escalation starting at lower levels (e.g., 2 mg)

Without specific steps to protect muscle eating enough protein and doing resistance exercise the body has no strong signal to preserve its lean mass during rapid weight loss

Overall, the primary composite endpoint occurred in 331 patients of 1767 (18.7%) on Ozempic (1 mg) and 410 patients of 1766 (23.2%) on placebo (HR, 0.76 [95% CI: 0.66-0.88] P =0.0001 for superiority)

Bonus Insight: What to Expect with Semaglutide Semaglutide is typically administered via a small injection once a week