Structural optimization: Further reduce IGFBP binding ability through site directed mutagenesis, or introduce transmembrane peptides to enhance tissue penetration
Statistical parameters were calculated using the Design Expert program version (13.0.5.0, Stat-Ease Inc., USA) (Singh et al
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In addition to glutathione IV therapy, try to avoid factors that may increase free radical levels, such as smoking, poor diet, misuse of alcohol, stress, inadequate sleep patterns, environmental toxins, and excessive sun exposure