Pyocyanin, being a zwitterion, diffuses across the host cell membrane and undergoes redox reactions by accepting electrons from NADPH which it subsequently donates to molecular oxygen to form primarily O 2 - and subsequently H 2 O 2 through dismutation ( The results detailed in Figure 5 provide a means to explain the pyocyanin/GPx/GRed/GSH interplay: that is, pyocyanin increases the level of ROS, and this leads to enhanced GPx activity in A549 cells because GPx catalyzes the reaction through which GSH neutralizes H 2 O 2
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PQQ and CoQ10 potentiate each other by helping to modulate the signal pathways between cells by preventing damage from oxidative stress and free radicals
37 No single measurement of TSH should be considered diagnostic, and repeated testing may be necessary for optimal treatment
