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Phase 2 cagrilintide alone ~10.8% body weight reduction at 26 weeks (4.5mg) Phase 2 CagriSema combo ~15.6% body weight reduction at 32 weeks Phase 3 REDEFINE 1 ~22.7% body weight reduction at 68 weeks Phase 2 CagriSema combination trial The Phase 2 trial of CagriSema was published in The Lancet in 2023, and its results attracted immediate attention
The practical takeaway was that Hospira remained fairly stable for 0-90 days, but by 120 days the benzyl alcohol level had noticeably declined to around 0.71%, roughly a 25% reduction from baseline
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