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A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction
If Phase II is too slow, the reactive Phase I intermediates accumulate and cause oxidative damage, DNA mutations, and cellular inflammation
Deionized water was used throughout the experiments to prepare the modified Tyrodes solution
According to DRAP: Oral glutathione is a health supplement or nutraceutical rather than a drug Topical products are considered cosmetic products rather than pharmacy-prescribed ointments
These medications have been shown to lead to significantly lower self-reported hunger, reduced food intake, and increased awareness around hunger cues and eating in response to environmental or emotional triggers
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