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The skin, which constitutes the outermost layer of the body, provides protection against external stimuli and performs various vital functions, such as regulating the release of inflammatory cytokines to defend the body when exposed to different environmental conditions [23, 31]

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Previously, we found that rotenone could negatively regulate mTOR-mediated p70S6K and 4E-BP1/Eif4E pathways, that leads to caspase-3 dependent neuronal apoptosis in vitro 15

This combination may interact with chemotherapy medicines (like doxorubicin and cisplatin), aluminum-containing antacids (like maalox), estrogen-containing medications (like estradiol), protease inhibitors (like indinavir), statins (like atorvastatin) and anticoagulants (like warfarin)