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Hypoglycaemia risk increases when Ozempic is combined with sulfonylureas or insulin, requiring dose adjustment of concomitant medications

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While direct combination data with GLP-1 receptor agonists remain limited and still evolving, the mechanistic rationale is straightforward: if GLP-1 therapy is driving significant weight loss and a meaningful fraction of that loss would otherwise come from muscle, then supporting testosterone levels provides a biologically coherent way to shift the composition of that loss toward fat rather than lean tissue

Compounded versus brand-name outcomes An important consideration that dosage charts alone do not capture is consistency of the active ingredient