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In SUSTAIN-6, wherein semaglutide (subcutaneous injection) was administered at 0.5 or 1 mg per week, MACE was also reduced by 26% in the semaglutide group compared with the placebo group (HR 0.74, 95% CI 0.580.95) as was stroke (HR 0.61, 95% CI 0.380.99) [17]
These changes are often related to fluid shifts or normal body adjustment to the medication
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L.OplandD
A further post hoc subgroup analysis was performed for RCTs specifically designed for body weight reduction
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