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The most common GI side effects include: Nausea: Often the most prevalent side effect, with incidence rates in some trials reaching up to 18% in the Tirzepatide groups, compared to lower rates in placebo groups
Why so gradual
This provides an immediate thickening effect and protects against environmental stress
Clinicians should maintain perspective: the substantial metabolic benefits of tirzepatideincluding HbA1c reduction averaging 2.0-2.5% in type 2 diabetes trials (SURPASS) and weight loss of 15-20% in obesity trials (SURMOUNT)may confer overall cardiovascular benefit that outweighs any theoretical concerns about clotting risk, though this requires confirmation from long-term outcome studies
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