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With GLP-1, dietary adjustments are necessary but not extreme to handle the muscle and intestinal effects of the drug

GLP-1s were never meant to be a quick fix or magic bullet

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GLP-1 expression was downregulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expression of lipolysis and autophagy-related genes and proteins were also inhibited, such as adipose triacylglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and hepatic lipase deficiency gene (LIPC)