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Watanabe et al used topical oxidized glutathione (GSSG) on 30 subjects in a split face randomized double blind placebo-controlled trial

Anytime you introduce a novel peptide sequence into a biological system, there is a non-zero risk that the immune system could misidentify it, leading to an unwanted inflammatory cascade or even a targeted autoimmune reaction

Based on patterns observed in clinical trials and the known pharmacology of the drug class, monitoring would likely need to be most intensive during the dose-escalation phase, when haemodynamic effects are most pronounced

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IV Drip Vs Intramuscular Injection IV drip: Delivers glutathione slowly through a vein