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A microdosing-like approach was also applied to an MC4R KO mouse model (Fig
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The half-lives of compounds 1 , 2 , 5 , 9 , 11 , 14 , 16 , 22 and 23 in presence of NEP 24.11 and in presence of mouse plasma were determined by following the decay of the analogues by LCMS (Table 2)
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