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10.1021/jm901137j 8 BaluchnejadmojaradT.RoghaniM

The mechanism of AOD 9604 in subcutaneous adipose tissue Activation of fat breakdown (lipolysis) AOD 9604 promotes fat breakdown through the following pathways: Activation of the 3-AR signaling pathway: AOD 9604 binds to 3-AR on the adipocyte membrane, activates adenylic acid cyclase (AC), increases the intracellular cyclic adenosine monophosphate (cAMP) level, and thereby activates protein kinase A (PKA)

Allow time for effective absorption before moisturizing

Note: This is not FDA-approved for human consumptionits strictly for research purposes

The path forward For 5-amino-1mq to move from research compound to established therapy, human clinical trials are needed