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As for CASP3, studies have shown a correlation between abnormal expression and BRCA patient prognosis, and an abnormal CASP3-mediated apoptosis pathway is a potential mechanism of chemoresistance in BRCA 40,41

Nature 514:181186 Sun Z, Wang W, Li L, Zhang X, Ning Z, Mayne J, Walker K, Stintzi A, Figeys D (2022) Comprehensive assessment of functional effects of commonly used sugar substitute sweeteners on ex vivo human gut microbiome

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