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For example, a small number of subjects reported the following mild side effects in the course of a four-week glutathione study at the dose of 1g/day [13]: Flatulence Loose stools Flushing Weight gain In a more specialized study involving cystic fibrosis patients and much higher glutathione doses, some of the patients reported tightness in the torso, diarrhea, and fever-like symptoms [14]

While you are supplementing, your cells have an extra layer of protection

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Functional signs that may suggest undermethylation or impaired methylation efficiency include: High internal tension Perfectionism, rumination, or OCD traits Chronic anxiety Low serotonin or low motivation Poor response to SSRIs Sensitivity to folate or methyl donors Increased inflammation Elevated homocysteine with normal or low B-vitamin status A methylation test that measures SAM, SAH, and homocysteine helps clarify the exact biochemical pattern