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Yu ZY et al
Efficacy endpoints were change from baseline in HbA 1c and body weight (and, for the separate PIONEER 8 subgroup analysis, change from baseline in insulin dose) at the planned end of treatment (weeks 26, 52 or 78, according to the trial)
Data from a lactation study with the oral tablet formulation reported drug levels below the lower limit of quantification in human milk
For many, butyrate is used to improve symptoms of gas, bloating, and constipation which is particularly helpful when fighting SIBO (which thrives on slow gut motility)
Despite the various pharmacological effects of SIN in treating cerebral ischemia, its short half-life and low bioavailability increase the risk of adverse reactions
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