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Studied in preclinical beta-3 adrenergic receptor-mediated lipolysis models and more recent chondroprotection research

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The decision to proceed to the next dose level was made by a safety group with access to a blinded clinical safety report prepared by the investigator and blinded preliminary pharmacokinetic data for semaglutide

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Reported side effects are generally mild the most common is injection site irritation, and some patients report transient nausea with oral dosing