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Additionally, the combined effects of oxidative stress and excitotoxicity activate both caspase-dependent and caspase-independent apoptotic pathways, leading to cellular fragmentation and neurodegeneration

Metivier R, Gallais R, Tiffoche C, Le Peron C, Jurkowska RZ, Carmouche RP et al

(3) The IgA-TG2 antibodies are locally produced in the small intestinal mucosa

7.3 Transgenerational and epigenetic research priorities While animal studies consistently demonstrate heritable reproductive dysfunction through EED-induced epigenetic modifications, human evidence remains limited, necessitating focused research initiatives to validate these mechanisms in human populations