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Key Takeaways Wegovy Pill (oral semaglutide, 25 mg, Novo Nordisk) was FDA-approved for weight loss on December 22nd, 2025 with the medication expected to be available to patients in early January 2026

However, gene duplication would mean an increase in gene dosage, which would likely be deleterious as insulin release and glucose tolerance is sensitive to GLP-1 dosage 38,39

Its short half-life, however, required it to be injected several times a day, which limited its appeal as a drug, and the company ran out of funding

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