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This creates a vicious cycle: damaged blood vessels lead to nerve death, and dead autonomic nerves further impair blood vessel function

Additionally, erythrocytes can scavenge chemokines via Duffy antigen receptor for chemokines (DARC), leading to changes in their availability and consequent regulation of immune cell migration [57]

GLP-1 receptor agonists have demonstrated significant weight loss results in clinical trials, with participants losing 15% to 22% of body weight over 68 weeks