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The top 10 most strongly regulated genes included the elongation of very long chain fatty acids protein 6 (Elovl6), ephrin type-B receptor 2, cell death-inducing DFFA-like effector A, malic enzyme 1, arrestin domain-containing 3, fatty acid synthase (Fasn), ACC a (Acaca), cytochrome P450 3A41A, cytochrome P450 4A12B and metallothionein 1

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"These drugs can be foundational treatments for obesity, diabetes, heart disease, and even heart failure." But access remains the biggest barrier, especially for people who don't meet strict insurance criteria

In the SOUL trial, published in March 2025 in the New England Journal of Medicine , researchers studied 9,650 participants aged 50 and older with type 2 diabetes and either cardiovascular or kidney disease