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So, how do clinicians strike the right balance between achieving tight control and avoiding overtreatment

A reasonable framework is to get a full baseline panel before you start, then recheck the markers that move

The high-affinity GABA transporters have been cloned and four distinct transport proteins have been described three of which are specific for GABA and one is able to transport both GABA and the osmolyte betaine [for references, see Ref