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One proposed mechanism involves adenylyl cyclase activity, which could raise cyclic AMP (cAMP) levels and activate protein kinase A (PKA)

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Reduced body fat means less insulation, making it harder to maintain core body temperature in cooler environments

Moreover, cell membrane expression of IGF-IR is present in 36% of head and neck squamous carcinoma (HNSCC), while cytoplasmic IGF-IR is detected in 92% of HNSCC [42]