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Although bariatric surgery led to more weight loss, GLP-1 RAs were associated with better outcomes, suggesting benefits may extend beyond just weight reduction

See the KPV dosage protocol for monotherapy reference dosing

Compared to the nausea that many people experience during dose escalation, or the dietary adjustments required when appetite changes dramatically, a red bump that fades in a few days barely registers on the inconvenience scale

When those receptors change signaling in the gut and brain, you get weight loss benefits, and the same pathways also cause many of the side effects people feel

Results revealed that RGC was significantly higher (5.4%) in patients with T2DM on GLP-1 RAs (semaglutide, liraglutide, and dulaglutide) compared to 0.49% in patients without T2DM on GLP-1 RAs ( p -value 0.004) [17]