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Untreated PKU leads to severe intellectual impairment, however, the precise mechanism by which this enzyme deficiency leads to the severe neural degeneration is not fully understood

Klopot A, Baida G, Bhalla P, Haegeman G, Budunova I

It holds an FDA approval from 2010 and has been examined in multiple randomized controlled trials for visceral adipose tissue in adults with HIV-associated lipodystrophy

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