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Available evidence does not establish one glutathione form as universally superior, and recommendations should reflect individual need, formulation quality, tolerance and clinical context
Human data is limited to a handful of trials, and its development program ended before approval
Supplementation may cause accumulation and oxidative paradoxhigh antioxidant levels can promote pro-oxidant effects in these contexts
(2019) Nat Rev Cardiol | doi: 10.1038/s41569-018-0108-7 Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL.: Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans
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