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Chills that will not respond to extra layers or heat, chills alongside a fever above 100.4 degrees Fahrenheit, symptoms lasting more than two weeks, or a pattern that keeps worsening all warrant prompt provider contact those can signal infection or a problem unrelated to the medication

History of neuropathic conditions People with pre-existing conditions involving nerve sensitivity, such as fibromyalgia, diabetic neuropathy, or chronic pain syndromes, may be at elevated risk

Do not have personal or family histories of certain medical conditions or allergies

Arch Biochem Biophys 615 , 2234, (2017)

Accepted: Sep 19, 2021 DOI: Download citation