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Incretin-based therapies work either by preventing enzymatic degradation of GLP-1, thus maintaining plasma levels of endogenous GLP-1 (dipeptidyl peptidase 4 inhibitors, DPP4is) or by directly activating GLP-1 receptors and mimicking the action of native GLP-1 (glucagon-like peptide-1 receptor agonists, GLP-1 RAs) [9]
Abstract Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are two incretins that bind to their respective receptors and activate the downstream signaling in various tissues and organs
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Abebe TB, Gebreyohannes EA, Tefera YG, Abegaz TM
Current Availability and Regulatory Status in the UK Retatrutide is not approved by the MHRA or EMA as of 2025 and cannot be legally prescribed in the UK
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