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importantly, the context-dependent effects of Metformin, including its reduced benefit in APOE-4 carriers and potential risks in non-DM2 populations, emphasize the need for stratified patient selection when considering DM2 DMTs for AD prevention
In clinical studies, liraglutide led to up to 44% reductions in liver fat and reduced prevalence of NAFLD by two-thirds in PCOS patients
Women of childbearing potential must use effective contraception during treatment and add non-hormonal backup contraception for 4 weeks when initiating or increasing tirzepatide doses due to potential decreased oral contraceptive effectiveness
Because semaglutide slows stomach emptying, large meals may increase nausea, bloating, fullness, reflux, or vomiting
When prescribed and monitored by a physician using appropriate lab work and clinical assessment, BHRT has a strong safety profile
