You mentioned gut, and I think its probably worth noting that, you know, the largest concentration of diamine oxidase is in the lining of the gut, meaning if you have any digestive issues, gastrointestinal inflammation, you immediately lose that, you know, frontline histamine-metabolizing layer, which also then leaves you more vulnerable to reactions to dietary histamines, because its DAO that would normally take care of those for you
Reported by Alan R
If you develop symptoms such as severe persistent abdominal pain with vomiting, or signs of pancreatitis whilst taking GLP-1 medications, seek urgent medical help (call 999 or go to A&E)
This cascade of oxidative stress can lead to cellular dysfunction and damage, significantly impacting various tissues and organs [174, 175]
No poor mucosal integrity weakens hormone signaling and increases inflammation, reducing GLP-1 effectiveness