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They are super popular for a reason: they work really well, said Dr Christopher Weber, an internist in Milwaukee who only sees patients struggling with obesity
Subcutaneous injection provides systemic distribution, but topical application targets specific areas of concern
They serve as key signaling molecules in the microbiota-gut-brain axis, directly influencing the central nervous system by crossing the BBB and indirectly modulating neurophysiological processes through immunoregulatory, endocrine, vagus nerve-mediated, and circulatory pathways
According to the Diabetes Atlas released by the International Diabetes Federation (IDF), the prevalence of diabetes among adults aged 20 to 79 around the world has reached 11.1%, and about 589 million people have been affected (Duncan et al., 2025)
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