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contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 Risk of diabetic retinopathy complications in patients with pre-existing retinopathy Potential for acute kidney injury, particularly related to dehydration Caution or avoidance in severe gastroparesis or severe gastrointestinal disease Suicidality warning for weight-management indications (Wegovy, Saxenda) Potential for altered absorption of oral medications due to delayed gastric emptying In older adults with cognitive impairment, medication adherence may be challenging, and gastrointestinal side effects could lead to dehydration or nutritional deficiencies

At our practice, we emphasize the integration of these medications with lifestyle modifications, including a balanced diet and regular physical activity

Exerkines as adjunct therapy in DR: clinical integration Anti-VEGF therapy remains central to DR management but does not directly address systemic metabolic and inflammatory drivers of disease and is associated with a substantial real-world treatment burden and adherence challenges (255, 256)

Favorece a sade cardiovascular ao melhorar a utilizao de lipdios como fonte de energia

Vitamin B6, especially in its methylated form, aids in neurotransmitter synthesis and energy production