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[96] have proposed that balanced GIP co-activation may buffer excessive GLP-1R stimulation within central emetic circuits, thereby improving therapeutic tolerability

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The relationship between GLP-1 medications and mood is complex and not fully understood

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Depressive-like behavior - In male rats, supplementation with N-3 PUFAs (postnatal day (P)41-61) [41] or sodium butyrate (P60-67) [42] mitigated the postnatal stress (POS)-induced depressive-like behavior in the forced swim test (FST) at two months of age [41] and at P67 [42]