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Mast cell activation and response to tolterodine in the rat urinary bladder in a chronic model of intravesical protamine sulfate and bacterial endotoxin-induced cystitis

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At the 12 mg dose: 28.3% average weight loss (about 70 lbs) 45.3% of patients lost 30% or more of their body weight 65.3% of patients dropped below a BMI of 30 Patients with baseline BMI 35 who stayed for 104 weeks lost 30.3% on average (85 lbs), with no plateau in sight Discontinuation due to side effects: 11.3% at 12 mg vs

Difficulties consist of erratic absorption, skin irritation from topical formulations, and no definitive timing recommendation with respect to ovulation or ART