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J Ann Rheumatic Dis (2018) 77(Suppl 2):6034

As an alternative methyl donor, betaine plays a central role in maintaining methylation capacity, and its depletion may contribute to elevations in S-adenosylhomocysteine and impaired methyltransferase activity

Therefore, this review summarized the potential mechanisms involved in the regulation of bone metabolism by MOTS-c and further explored the possible mechanisms involved in the regulation of bone metabolism by exercise, with a view to providing a theoretical basis for subsequent studies

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Risk factors determine who benefits