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Microenvironment-responsive phototherapeutic platforms that sense biochemical cues including redox status allow activation only within pathological niches, improving safety and enabling synergistic combinations with GSH-consuming or GSH-responsive agents to bias tumor redox balance toward therapeutic ROS generation [21]

They can help fade dark spots over time, but additional treatments like serums or creams may be needed for stubborn pigmentation

PTGS2 prostaglandin endoperoxide synthase 2