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Severity Assessment: Low but Not Zero Major drug interaction databases (Lexicomp, Micromedex, Clinical Pharmacology) do not flag tirzepatide plus progesterone as a contraindicated or even "major" interaction
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Conversely, if blood pressure remains elevated despite Ozempic therapy and lifestyle measures, intensification of antihypertensive treatment may still be necessary
Hypokalemia All insulins, including TRESIBA, cause a shift in potassium from the extracellular to intracellular space, possibly leading to hypokalemia
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