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Mild injection-site reactions are the most common observation

Thus, although the independent audit of all data carried out by regulatory authorities in the US and EU did not find evidence to support a causal relationship between incretin therapies and pancreatitis (131), it cannot be ruled out that a small increased risk of acute pancreatitis may exist in susceptible patients treated with DPP-4 inhibitors

They can tease out the impact of these factors from the impact of the medications

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