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To be considered for tirzepatide treatment, clients should meet the following requirements: A Body Mass Index (BMI) of 30 kg/m or higher, qualifying as obesity, or a BMI of 27 kg/m or higher if accompanied by at least one weight-related health condition, such as Type 2 diabetes, hypertension, dyslipidemia (high cholesterol or triglycerides), obstructive sleep apnea, or nonalcoholic fatty liver disease (NAFLD)

All of this has to do with the pharmacokinetics of the medication you're taking

In Phase 2 trials, retatrutide at 12 mg produced an average 24.2% body weight loss at 48 weeks