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Tirzepatide works on two receptors (GLP-1 and GIP), while retatrutide works on three, adding glucagon receptor activation
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At the same time, in old treated animals, the dynamic of oxygen cost of myocardial work did not differ from the untreated group (Figure 4E) that might be due to compensatory mechanisms in myocardium developed with aging
For example, the hindbrain is responsible for integrating information necessary for energy homeostasis from diverse systems, including vagally mediated gastrointestinal signals, alterations in glucose and other circulating metabolites and descending neuroendocrine signals from the midbrain and forebrain 3
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