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This was remarkable because the cardiovascular benefit was demonstrated independently of glucose-lowering effects, since the participants did not have diabetes to treat
Timelines vary by starting point
12-14 In phase III clinical studies in which exenatide was administered concomitantly with metformin, an SU, or metformin plus an SU, 48% of the 483 patients receiving exenatide 10 mcg twice daily reported nausea compared to 18% of the 483 patients receiving placebo
When combining peptides, it is advisable to start with conservative doses of each compound and gradually adjust based on individual response and tolerance
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